If you look at the curves on transmission fluid it seems to be most stable from 130 to 180. I know Dexron IV starts falling apart above 250. There is a GM specification, GMN10060, that might be useful to you.
I usually add a large one in front of the radiator, then pipe it back through the radiator tank (ever notice they're always on the cold side of the radiator?). On my offroad crap I skip the radiator (because the transmission is always 200+).
My Silverado has a 6L80e and even when beating on it towing when it's hot out it has only ever gotten to 197. Most of the time it's from 130 to 165.
Over-cooling is bad also. Until I've cooked the fluid a few times, my offroad crap will put your head in the back window in the 2-3 shift (700R4) after startup.